| Population | |||
| County | 2010 | 2000 | % Change |
| Nacogdoches | 64,524 | 59,203 | 9.0% |
| City | |||
| Nacogdoches | 32,996 | 29,914 | 10.3% |
| Nacogdoches Economic Market | 313,579 | 289,290 | 8.4% |
| Angelina County | 86,771 | 80,130 | 8.3% |
| Cherokee County | 50,845 | 45,659 | 11.4% |
| Nacogdoches County | 64,524 | 59,203 | 9.0% |
| Panola County | 23,796 | 22,756 | 4.6% |
| Rusk County | 53,330 | 47,372 | 12.6% |
| San Augustine County | 8,865 | 8,946 | -0.9% |
| Shelby County | 25,448 | 25,224 | 0.9% |
| SOURCE: U.S. Census 2010 | |||
| Population Growth (1990-2015 Projected) — Nacogdoches County | |||
| Year | Population | ||
| 1990 | 54,753 | ||
| 2000 | 59,203 | ||
| 2010 | 64,524 | ||
| 2015 * | 65,919 | ||
| Change 1990-2000 | 8.1% | ||
| Change 2000-2010 | 9.0% | ||
| Change 1990-2010 | 17.8% | ||
| Change 2010-2015 | 2.2% | ||
| SOURCE: U.S. Census Bureau, *Nielsen-Claritas, Inc., Wadley-Donovan GrowthTech | |||